World’s First Clinical Trial for anti-Abeta Vaccine Targeting Alzheimer’s Disease-like Characteristics in People with Down Syndrome

Categories: Blog, Clinical Trials, Ds / Alzheimer's Connection, Ds Research, News

AC Immune

PRESS RELEASE – Issued by AC Immune

  • Studies AC Immune’s ACI-24, the first anti-amyloid vaccine for treatment of Alzheimer’s disease-like characteristics in people with Down syndrome
  • Clinical Study is done in collaboration with University of California San Diego
  • US NIH provides significant funding with an additional grant from the LuMind Research Down Syndrome Foundation
  • Alzheimer’s disease-like characteristics develop in virtually all people with Down syndrome over age 40; majority develops associated dementia over
    age 60

Lausanne, Switzerland, San Diego, CA and Marlborough, MA USA – January 7, 2016 – Today plans were announced to conduct the world’s first clinical trial for a vaccine targeting Alzheimer’s disease-like characteristics in those with Down syndrome. The study will test AC Immune’s vaccine ACI-24 and is being conducted in collaboration with the University of California, San Diego (UC San Diego) Down Syndrome Research and Treatment Center. Funding is provided by a significant grant from the US National Institutes of Health (NIH) and an additional grant from the LuMind Research Down Syndrome Foundation. This is the first public/private collaboration for a clinical trial in the field of Down syndrome.

Individuals with Down syndrome (DS) have an extra copy of chromosome 21 which carries the gene for APP encoding the precursor protein of Abeta, one of the hallmarks of Alzheimer’s disease (AD). An important consequence is that individuals with DS develop AD-like characteristics at a rate three to five times greater than that of the general population and at a much younger age. Further, AD-like characteristics develop in more than 98% of people with DS over age 40 with up to 80% developing associated dementia over the age of 60. It is estimated that there are 6 million people with DS worldwide, with 400,000 in the United States.

Trial participants will be adults with DS. The objectives of the trial include studying safety and tolerability of ACI-24, its effect on induction of antibodies against Abeta, clinical and cognitive measures in adults with DS and its effect on biomarkers of AD-like pathology in DS. Participants in the study will be treated for 12 months, with 12 months follow up.

Prof. Andrea Pfeifer, CEO of AC Immune said: “We are very pleased to bring this potentially disease modifying treatment for Alzheimer’s disease into the vulnerable, genetically predisposed Down syndrome population. The combined knowledge and resources of AC Immune, UC San Diego, NIH and the LuMind Research Down Syndrome Foundation should generate much needed insight for treating the Alzheimer’s-like characteristics of those with Down syndrome. Additionally, this ground-breaking clinical trial could enhance our understanding of early intervention and prevention of Alzheimer’s in general.”

Dr. William Mobley, Executive Director of the UC San Diego Down Syndrome Research and Treatment Center, commented: “We are delighted to join our colleagues at AC Immune and the LuMind Research Down Syndrome Foundation in this exciting study, the first step in a process whose ultimate goal is preventing Alzheimer’s disease in people with Down syndrome.  That both public and private funding sources support the study signifies the importance attached to Alzheimer’s disease and the valuable insights that will come from studies of this disorder in Down syndrome.  We wish to thank our colleagues as we eagerly look forward to helping people with Down syndrome and their families and loved-ones.”

Dr. Michael Harpold,  LuMind Research Down Syndrome Foundation’s Chief Scientific Officer, stated: “We are very excited the LuMind Research Down Syndrome Foundation has been able to work and join together with AC Immune, UC San Diego and NIH in establishing the first ever private-public partnership for a clinical trial in the field of Down syndrome. Accelerating research and the development of new potential therapies to address the developmental intellectual disabilities and earlier onset of Alzheimer’s disease in people with Down syndrome represents a major part of our foundation’s mission and commitment to prevent the earlier decline and loss of important gains they have attained throughout their lives.”

About ACI-24

ACI-24 is a liposomal therapeutic anti-Abeta vaccine candidate, which is owned by AC Immune and was discovered utilizing the Company’s proprietary SupraAntigenTM technology platform. The vaccine is designed to stimulate a patient’s immune system to produce antibodies that specifically target the oligomeric and fibrillary Abeta proteins to prevent beta amyloid plaque accumulation and to enhance plaque clearance. Preclinical data demonstrated a significant activity in plaque reduction and memory restoration as well as a favorable safety profile characterized by a lack of local inflammation and a mode of action independent of inflammatory T-cells. The vaccine is currently also being studied in a phase 1/2a clinical trial in patients with mild to moderate AD, in which no significant safety issues have been detected to date.

About Down syndrome

Down syndrome, or trisomy 21, is the most common genetic cause of intellectual disability and developmental delay, and affects one in 700 newborns. This condition results when an individual has three, rather than two, copies of the 21st chromosome. This additional genetic material causes impairment of cognitive ability and physical growth, and is associated with other medical issues ranging from neurological and cardiac defects to hearing and vision problems as well as earlier development of Alzheimer’s disease. The average life expectancy for people with DS has increased from 25 years in the 1980’s to approximately 60 years today.

About Alzheimer’s disease

It is becoming increasingly clear that Alzheimer’s disease develops because of a complex series of events that take place in the brain over a long period of time. Two proteins – Tau and beta-amyloid (Abeta) – are recognized as major hallmarks of neurodegeneration: tangles and other abnormal forms of Tau protein accumulate inside the brain cells and spread between cells, while plaques and oligomers formed by beta-amyloid occur outside the brain cells of people with AD.

AD is one of the biggest burdens of society with a dramatic and growing worldwide incidence rate of one new case every three seconds, or 9.9 million new cases of dementia each year. Since the incidence and prevalence of AD increase with age, the number of patients will grow significantly as society ages. Worldwide in 2015 there are 46.8 million people living with dementia and by 2050 it is expected that global patient numbers will triple to 131.5 million. It is estimated that the annual societal and economic cost of dementia has risen from US$ 604 billion in 2010 to US$ 818 billion in 2015.  In the US, AD is now the 6th leading cause of death across all ages and is the fifth leading cause of death for those aged 65 and older.

About AC Immune

AC Immune is a leading Swiss-based biopharmaceutical company focused on neurodegenerative diseases with three product candidates in clinical trials.  The Company designs, discovers and develops therapeutic and diagnostic products to prevent and modify diseases caused by misfolding proteins. AC Immune’s two proprietary technology platforms create antibodies, small molecules and vaccines to address large markets across a broad spectrum of neurodegenerative indications. Alzheimer’s disease (AD) is the largest indication addressed by its products but the company’s innovative, differentiated and disease-modifying therapies are designed to shift the paradigm in the treatment of other neurodegenerative diseases such as Parkinson’s, Down syndrome, and Glaucoma. The Company has a large, diversified and promising pipeline featuring seven therapeutic and three diagnostic product candidates. The most advanced of these is crenezumab, an anti-Abeta antibody that is licensed to Genentech entering phase 3 clinical trials. Crenezumab was chosen by the US National Institute of Health for use in the first-ever AD prevention trial. The company has partnered three programs targeting Tau: ACI-35 with Janssen (therapeutic vaccine, phase 1b), Tau-PET imaging agent with Piramal (Alzheimer’s diagnostic agent) and anti-Tau-antibodies with Genentech (preclinical). The anti-Abeta vaccine ACI-24 phase 1/2a trial is run in house.

About UC San Diego Down Syndrome Research and Treatment Center

Established in 2009, the Center’s efforts focus on defining the genes and mechanisms responsible for the cognitive challenges faced by people with Down syndrome. Studies are carried out in both mouse models and in mouse and human cellular models.  The insights derived support translation of basic science findings into new treatments, using either existing drugs or through drug discovery. The Center’s work has resulted in conceptual innovations and several novel treatment targets and has inspired existing trials as well as the clinical study announced in this press release (supported by an NIH grant under award number R01AG047922). The Center is supported by the NIH and private foundations, including the LuMind Research Down Syndrome Foundation, the Alzheimer’s Association, the Tau Consortium and the Cure Alzheimer Fund.

About LuMind Research Down Syndrome Foundation

LuMind Research Down Syndrome Foundation, formerly the Down Syndrome Research and Treatment Foundation (DSRTF) and Research Down Syndrome, is an international non-profit organization with headquarters in Marlborough, Massachusetts, aimed at accelerating the development of treatments to significantly improve cognition, including memory, learning and speech, for individuals with Down syndrome. LuMind RDS Foundation is the leading source of private funding supporting Down syndrome cognition research at major research centers, including Johns Hopkins Medicine, Stanford University, University of California, San Diego, and University of Arizona. Since its founding in 2004, LuMind RDS Foundation has committed more than $13 million to fund results-driven research programs that will benefit children and adults with Down syndrome, and has been instrumental in the initiation of clinical trials now under way.

For further information please contact:

AC Immune

Prof. Andrea Pfeifer

Chief Executive Officer

Phone: +41-21-693 91 21

Eva Schier

Corporate Communications Manager

Phone: +41-21-693 91 34



Nick Miles

Senior Consultant

Cabinet Privé de Conseils s.a.

Mobile : +41 79 678 76 26

E-mail :

In the US

Ted Agne

The Communications Strategy Group Inc.

Phone: +1 781 631 3117

E-mail: edagne@comstratgroup.comed



UC San Diego

William C Mobley, M.D., Ph.D.

Professor of Neurosciences, and

Executive Director, Down Syndrome

Research and Treatment Center

Phone: +1 858-534-9434



Scott LaFee

Director, Media Relations

Marketing and Communications

UC San Diego Health Sciences

Phone : +1 619-543-6163

Email :


LuMind Research Down Syndrome Foundation

Carolyn Cronin

President/Chief Executive Officer

Phone: (508) 630-2178



Ellen Oliver

Marketing Director

Phone: (508) 630-2179



Michael M. Harpold, PhD

Chief Scientific Officer

Phone: (520) 297-3105




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  56. 家を守る機能で最も重要なファクターは、耐力性能で壁の厚さ、強固性、耐用年数がその壁の性能の要素です。デザインもそれと同等ぐらい重要ですが、デザイン、色、意匠ばかりに目がいって耐力性能が疎かになっていなでしょうか?メーカーではなく我々消費者も外壁についてお勉強しましょう。

  57. はじめまして。僕は明後日で28歳と5カ月になります。そして夏日が多い日になりました。ですからやっぱり無駄な毛は脱毛をやっておきたいですよね。最近は、全国に脱毛できる病院がたくさんあります。やりたい部位は、人によりますが、特に多いのはアンダーヘアです。私は、店舗が多いシースリーに通っています。そのおかげで、かなりムダ毛がなくなっています。やはり個人で処理するのとは、効果が凄いです。もう少しシースリーに行ってムダ毛を減らしたいです。でも、医療クリニックに通ったとしても気になるのが脱毛にかかるお金です。それについては、脱毛ラボに聞けばいいでしょう。他にも気になるのが、どれくらい通わないといけないのかです。うちはできれば、一年くらいで完全に終わってくれると理想的ですね。まあ、今から行く人は相談してみましょう。

  58. 日本人の色彩感覚のひとつに浮世絵があります。その大胆な構図の中にも色の使い




  59. カラコンって、初めて注文する時やメーカーやショップを変える場合、スゴク悩み、考えるこ事になる私って、変ですか!






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  62. 脱毛エステシースリーの特徴は、全店使用の脱毛マシン「ルネッサンス」といえます。日本人特有のお肌や髪の毛に合わせた100%国産で自社開発の高機能マシンです。しかも、脱毛と一緒にジェルトリートメントによって肌を守ってくれる効果もあり、脱毛と一緒に美肌ができあがるという脱毛方法になります。

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  64. 自分のペニスを大きくするやり方はいっぱいとアリますが、効果的な方法が増大サプリメントをつかう事です。僕もペニス増大サプリをつかうことで、以前よりもおおきくなりました。だから、ペニスがこまいとおもっている人であれば、ぜひともペニス増大サプリを服用する事をお勧めします。わたしのHPでお勧めしているモノは、日本製で安心して使う事が出来ます。リアルに自分自身で服用して、効果がある増大サプリをお勧めしている為、オトナになった男性でも効果があると思います。増大サプリだけ服用してもペニスはBIGになりません。やっぱりpenisのトレーニングも効果的に行うべきです。ボク自身も、ペニスをデカくする際に、積極的にチントレもしました。チントレをしたあとに増大サプリメントを使用する。これがやはりいちばん効果のある男性器をおおきくする方法だと言えます。今、ペニスが小さいと悩んでいるオトコは、ぜひボクが推奨しているペニス増大サプリを取り入れてみて下さい。よろしかったらわたしのホームページへ観に来て下さい。

  65. オトコの更年期障害におすすめのサプリとして、精力剤と増大サプリメントがあります。精力増強剤とpenis増大サプリには男性ホルモンや成長ホルモンの生成を活発にする色々なモノがたくさん含まれています。男の更年期の症状はLOH症候群とも言われ、最近ではStress、生活習慣の乱れから若いオトコの人でもなる症状とされています。オトコの更年期障害は鬱病と症状が被っているため、ちがいが微妙という男の人も多い様ですが、ほとんどが中折れなどの性的なきのうが下がるのが特徴です。Viagraなどの勃起薬などのボッキかいぜんのサプリメントもありますが、それはエッチの時だけ有効ですので、男の更年期の症状には時間がかかりますが、男性ホルモンや成長ホルモンをカラダでつくる様なからだにするほうがメリットがあるのです。朝たちができているかた、また、勃起をしているだんせい、こういっただんせいは他のサプリメントを飲むほうが効果があると言われています。ボッキが殆どできないのであれば、せいりょく剤をのむ必要があります。すこしでもぼっきするコトがデキれば、ペニスを大きくするサプリの方が男性ホルモン(テストテロン)やせいちょうホルモンがぶんぴつされる成分が多いので有利です。代金はペニスを大きくするサプリの方が高額です。日本製で信頼アリです。

  66. エステ|脱毛サロン|脱毛専門エステ選びで失敗したり苦い思い|嫌な気持ち|ブルーな気分をすることは回避しなければなりません|避けたいものです|何とか避けましょう。以前|前に|これまでに申し込んだ|利用した|行ったことのない店|エステサロン|脱毛サロンで大がかりな|いきなり|手間のかかる全身脱毛の申込書に記入する|を契約する|を決めてしまうのは不安なので、ビギナープラン|お試しコース|格安体験で見極める|実際体験する|部分脱毛するのがいいのではないでしょうか。メンズ永久脱毛では、VIOゾーン|腕|胸などボディだけでなく、皮膚科|美容皮膚科|美容クリニックなどの医院やエステ|脱毛サロン|脱毛専門エステではひげ|ヒゲ|髭や顔|フェイスの永久脱毛もしています。ひげ|ヒゲ|髭や顔|フェイスの永久脱毛も電気を使用する脱毛やレーザー|医療レーザーを使用した|使った|肌にあてる脱毛で処理します。

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  68. 20代でも稀有なことでもなんでもなく、VIO脱毛でアンダーヘア処理を経験する時代になっており、とりわけアンダーヘアが不安な人、自宅でアンダーヘアをケアすることが難しいという女の子が目立ちます。

  69. お初にお目にかかります。いきなりでですが、私もサイトを営んでいるのでぜひご訪問下さい。多くの女性の皆様は今日まで、お家で独力でシェイプアップをされてきたのではありませんか。それで達成できる人もいるとは言えますが、想像通りに痩せなかったり、元に戻ってしまったり、苦労を重ねてもうまく行かなかった人も多いと思います。 そこでリバウンドなく、健全にダイエットするには、やはり痩身エステサロンに行く事も、とても効果的です。こちらでは、レビューで評価が高い、結果重視の痩身エステをリストにしていますので、ぜひ参考にしてみると良いですよ。私のブログは主にビューティ関係です。私自身が現実にトライした上で、オススメするコスメティックやスリミング方法、食事の献立やサプリなどもご紹介しています。特に痩身はなかなか順調に結果が出ないと思いますが、ワタシはオリジナルの方法を組み合わせて、かなり細くなることに成功しました。特に効果的に感じたのは痩身エステティックサロンです。エステサロンとなると、急に障害が高くなったように感じるかもしれませんが、今時ののエステはそんなことありません。若い会員さんを集めようと、どのエステサロンもとてもリーズナブルです。一般的にエステサロン選びで選択ミスをしない、より良い方法は、実際そのエステにおいて体験させてもらった人からの評判を聞くのが確実だと思います。ワタシのホームページでも、エステについても突っ込んで書いてあるので、是非参考にしてみてください。

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  79. れんきゅうもうの困ったことを回復させるやれることは、ヘアミスト等挙げられます。



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  83. 自身で脱毛すると、処理の仕方が悪いために毛穴が大きくなったり黒ずみが重症化したりすることも結構あります。脱毛サロンに行ってご自分に適合する施術を受けた方が良いでしょう。

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