Is Ds Research Advancing Alzheimer’s Disease Research – Or is it the Other Way Around?

Categories: Blog, Ds / Alzheimer's Connection

How are Down syndrome and Alzheimer’s Disease connected?

It is an interesting and surprising finding that every person with Down syndrome develops by age 40 the brain pathological changes of people with Alzheimer’s disease. Moreover, most people with Down syndrome in old age – i.e., beyond age 60 – show further cognitive decline. This is a devastating aspect of Down syndrome and one that is quite disconcerting for those that care for elderly individuals with Down syndrome.

The question is how to explain the link between Down syndrome and Alzheimer’s disease. There is no certain view at this time, however, some recent findings are very exciting. They point to a specific gene that is present in three copies in Down syndrome, which is known to be linked to Alzheimer’s disease. In ongoing studies, researchers are testing how this gene might contribute to the development of Alzheimer’s disease in people with Down syndrome.

How can research in Alzheimer’s disease help us understand and treat Down syndrome?

Because people with Alzheimer’s disease and elderly people with Down syndrome have the same pattern of brain pathology, it is reasonable to suppose that advances in understanding Alzheimer’s disease and new therapies to treat Alzheimer’s disease can be applied to people with Down syndrome. Indeed, this is already happening.

A number of studies are underway to test a role for cholinesterase inhibitors in people with Down syndrome. Cholinergic neurons are important for learning and memory and they are sick in both Alzheimer’s disease and Down syndrome. They release a neurotransmitter called acetylcholine. The breakdown of acetylcholine is under the control of molecules called cholinesterases. Drugs that decrease the activity of these enzymes increase the level of acetylcholine. This helps increase memory in people with Alzheimer’s disease, if only for a short time. Recent studies suggest that these drugs may also be used to treat Down syndrome. One can readily imagine that other therapies directed at Alzheimer’s disease might be made available to people with Down syndrome.

Conversely, studies on mouse models of Down syndrome may well provide new insights into how best to treat people with Alzheimer’s disease. Indeed, the research strategy for Down syndrome differs in some important ways from the typical strategy used to understand Alzheimer’s disease. Work on Down syndrome might provide an important new way of thinking about what causes degeneration of neurons in Alzheimer’s disease and how to treat or prevent it.

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Comments are closed.

198 responses to “Is Ds Research Advancing Alzheimer’s Disease Research – Or is it the Other Way Around?

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  20. Nice blog here! Also your web site loads up very fast! What host are you using? Can I get your affiliate link to your host? I wish my web site loaded up as fast as yours lol

  21. The very root of your writing while sounding agreeable at first, did not really sit well with me personally after some time. Somewhere throughout the paragraphs you actually were able to make me a believer but only for a while. I still have got a problem with your jumps in logic and you might do well to help fill in those breaks. When you can accomplish that, I would undoubtedly be impressed.

  22. How do I get traffic to a blog on tumblr?. I need people to find my blog through keywords but I cannot find the Webmaster device on tumblr to do this. Or the Sitemap tabs that supposedly exists. And the way to do passes. And I actually don’t understand the way i sign up my blog with search engines. May someone clarify this to a newbie as me personally? I’m getting into a blog contest partly judged on comments left on the page, so getting the traffic there is certainly important..

  23. You produced some decent points there. I looked on the internet for the concern and discovered most people will go along with together with your web site.

  24. I had choices from essays to video clips and I actually figured running a blog can be fun. Can you produce a good free of charge website and a little help on how to begin with what to state, and whether i put it under one day or do it every day until its due. Please help and I actually promise to choose you since the best response if it assists!.

  25. For the “letter to the editor, ” can one send his/her blog post to the editor. The instructions say: “Letters to the manager should just be sent to The Times, instead of to other publications. All of us do not publish open letters or third-party letters. inches.. Does that mean blog posts, too?.. Thanks a lot..

  26. Hello, I think your blog might be having web browser compatibility problems. Whenever I take a look at your web site in Safari, it looks fine however when opening in I.E., it’s got some overlapping issues. I simply wanted to give you a quick heads up! Besides that, great blog!

  27. I read many of the blogs in the food and drink category plus they are all helpful in one method or another. I love food and also have a great deal of meals design experience. Please tell me how I can become a blogger there..

  28. I have been given a Dell computer from my sibling. However , her former husband set up his account on this pc (says this individual cannot remember the password), making himself the only administrator. Right now, I cannot add any programs ( like iTunes), neither can I delete anything. How do i clear his passwords using this computer, and make me the boss? I are afraid that I shall have to delete almost everything, then start again (ugh! ) That could mean buying new applications, installing them and so on. Any kind of ideas?.

  29. There is it a little difficult to find pc parts without having to buy entire computers and tearing all of them apart personally.. I want to begin my own business using the pc parts, but where am i able to get the pc parts (the small parts)? I have attempted my local recycle center and no achievement.. I’m in the verge of contacting an established computer craftsperson and cosigning to their business… Anyone with ideas or advice?.

  30. Hey there! I know this is somewhat off topic but I was wondering if you knew where I could get a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

  31. I use three blogs on tumblr under the same email address. How can i delete one of those blogs with out deleting the other two?. Preferably, I’d like someone to remedy whom offers encountered this issue before and solved this without deleting their various other blogs.. Thanks a lot!.

  32. I want to create an article on my site to share with individuals. How can I make certain that no one copies what I have got written and claim this as their very own? Is there several place where I can “register” my function so that I use proof that it can be my work and no one particular else can claim this as theirs?.

  33. I am new to blog page subscriptions and I are looking intended for an easy reader that is nice and arranged that lets me watch my blogs from my homepage or has a little scrollbox that is certainly always up on the side from the computer screen. I started to make use of bloglines but it is really unorganized with all the blog page names lined up on the side. Thanks a lot!.

  34. I have a organised WordPress blog page. For some reason, my blog posts are being sent out to fans of one more blog. The other blog owners uses Blogger. We are able to figure out why or how this is happening?.

  35. I have always been 15 and I want to begin a fashion blog page. What should I call it? Also, please show me any tips you have got for getting began and what I could perform on it or how to do it..

  36. I know this if off topic but I’m looking into starting my own weblog and was wondering what all is required to get set up? I’m assuming having a blog like yours would cost a pretty penny? I’m not very internet savvy so I’m not 100 sure. Any recommendations or advice would be greatly appreciated. Appreciate it

  37. My desktop computer is hooked up to a router. I would really like to get access to my home computer’s web cam through my work computer.. My home computer is connected through a DSL modem and is often on.. My work computer obviously provides access to the Internet..

  38. My pal put together my small business site in dreamweaver for me. Nevertheless , I right now want to maintain it myself—my friend suggested putting it into wordpress. However , I am not a web designer and have no idea what I’m doing—is there an easy way to convert my current website from dreamweaver to wordpress (for someone who cannot read code, etc).. Thanks a lot!.

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  42. I actually made some songs and I want to understand how to alter the copyright laws content on an MP3 document so I can share this online? I wish to add (p) Swagers Studios (2009) to the copyright articles and was wondering if this was feasible. Any help is significantly appreciated.. It can still not really letting me edit the copyright content. Ive noticed that some MP3’s I downloaded off the world wide web have unofficial copyrights like ZOMG company. If you can’t help it’s okay.

  43. Do you mind if I quote a few of your posts as long as I provide credit and sources back to your webpage? My blog site is in the very same niche as yours and my visitors would genuinely benefit from a lot of the information you provide here. Please let me know if this okay with you. Thanks a lot!

  44. I have been given a Dell computer from my sibling. However , her former hubby set up his accounts on this computer (says he cannot keep in mind the password), making himself the only administrator. Now, I cannot add any programs ( like iTunes), neither can I delete anything. How can I clear his passwords out of this computer, and make personally the administrator? I am afraid which i shall have to delete almost everything, then start again (ugh! ) That could mean buying new programs, installing them and so on. Any kind of ideas?.

  45. Hey i have a vintage xp computer ant want to make it a client of my newer vista home superior computer. I actually hear that there is a program away there that whenever u boot up the (client computer) u come right to the welcome screen within the base pc (the one with vista on it) some how they are linked threw the network. Any ideas?.

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  47. This used to show at the top of my start list until I actually downloaded google-chrome to see what was about, I didn’t really like it so I deleted it but now firefox isnt at the top of begin. Any tips?.

  48. I use heard of websites and kind of know what they are. My question is exactly what do you write on the blog, like stuff that is on your mind or just whatever? And what websites can i logon to to begin blogs?.

  49. I’m in high school and starting the coming year I will have to start looking at colleges. I realize I want to look for a college just for creative writing. I love composing stories of most sorts, and I know of the couple schools that are experts in creative composing. But exactly where would you suggest? Remember, I’m just talking about creative writing, not really journalism. Any suggestions?.

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  58. Hi. Now i am looking for a great site that offers creative composing prompts or creative composing exercises since I heard that anyone that is serious about writing must do creative composing exercises. So does anyone know of a good one?.

  59. I want to blog page about problems I don’t want associating with my ‘work’ personal. How do I choose a blog host that has a great anonymity record, in other words, We don’t want it to be easy for people to match my IP address or access my own details.. Also, having established the blog up, how do you encourage high volume visitors?. I have only utilized LJ prior to and I would like to try something a bit different, but invisiblity is the biggest issue for me. Would welcome suggestions great free blog hosts..

  60. I live in Costa Rica and am going to publish a community newspaper, exactly what are the steps to go about copyrighting the name and articles published in it? And also when can one start using the copyright laws symbol?.

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  67. With havin so much content and articles do you ever run into any issues of plagorism or copyright violation? My blog has a lot of exclusive content I’ve either authored myself or outsourced but it seems a lot of it is popping it up all over the web without my agreement. Do you know any solutions to help reduce content from being ripped off? I’d truly appreciate it.

  68. My video gamer in joomla doesn’t play videos in firefox in the event that the latest flash player isn’t very installed. Let me have it just like a professional participant to show a dialog stating: “Do you want to install adobe flash player 10” or how it says when you go to a professional website so users do not have to search and download flash player manually….. Does anyone know, the right way to do this?.

  69. I really like the sciences, especially chemistry and physics. But I also love the innovative aspect of the spectrum, such as writing and books. I really wish to write. Would it be smart to minor in English or Creative Writing but major in the sciences? Will it look appropriate? I’m new to college stuff, and Now i’m curious. I don’t desire to miss an opportunity to progress my medical or innovative knowledge! Now i’m a Junior in high school..

  70. Like videos around the internet. I believe people should have to have proof, cause there are a lot of trolls, you know individuals with no existence that have nothing better to perform than ruin things for everyone else..

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  74. alright so i downloaded firefox. seems using chrome for a while, and everything a sudden after i x’ed away my chrome and opened up it again it will not go to websites, it wont actually say web page not shown. it will just be blank. so i unstalled this and lso are stalled this and this worked when it was launched in the reinstal nevertheless i x’ed it away again and opened this it demonstrated blank. does anyone understand how i can repair this????.

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  81. I’d see all kinds of ads about blogging on the Internet to make money, but how to start of anybody that has actually made anything this way. I’d personally love to listen to from anyone who has..

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  83. Everybody says you can’t move an initial Tumlbr blog without removing the account, but how about a secondary blog page? I have two accounts, one that I use and one that I simply started. I don’t use the primary blog within the old a single, but I do use a supplementary blog on the same account. Can there be any way I could move that secondary blog page to my new account as a supplementary blog as well?. Thanks!.

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